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TABMELT® – Sublingual Drug Delivery System

What is TABMELT®?

TABMELT® is a novel patented and patent-pending sublingual drug delivery system that allows patients to take a medication by simply dissolving a tablet under their tongue. This delivery route may lead to more instantaneous and accurate absorption than oral drug delivery.

Why TABMELT®?

Oral drug delivery is the most common drug delivery mechanism. Taking medications orally means that the treatment has to go through the largely acidic GI tract and the first-pass metabolism of the liver. This process suggests a larger minimally effective oral dose may be required to achieve optimum bioavailability, potentially leading to a higher risk of side effects.

Several factors influence the strategy for administering prescription drugs through specific drug delivery systems, including drug safety, systemic response, permeability, absorption, potency, efficacy, bioavailability, reactogenicity, pharmacokinetics, cost-effectiveness, and dose-response, among other factors. Sublingual drug delivery can be highly beneficial and advantageous among the various drug delivery routes. Targeted sublingual drug delivery may provide an alternative to oral drugs while potentially reducing the dose needed and possibly avoiding or limiting other delivery systems’ adverse side effects.

TABMELT® is a revolutionary, patented sublingual drug delivery system that will forever change the way patients take medications. The TABMELT® delivery system is a novel, all-natural, non-toxic sublingual drug delivery system that may offer a set-dose drug delivery system that enhances bioavailability and allows patients to dose by dissolving a tablet underneath the tongue.  

Comparing TABMELT vs. Oral Delivery

Among the routes for various drug deliveries, the oral route is the most preferred by patients and providers, but new sublingual delivery systems could be advantageous.  Review the chart below for a comparison between TABMELT and oral drug delivery.

TABMELT Oral Drug Delivery
Delivery
Sublingual delivery of drugs in the oral mucosal cavity is characterized by systemic delivery of drugs through the mucosal membranes lining the floor of the mouth (under the tongue). The skin under the tongue is part of the oral mucosa covering the entire inside of the mouth. The oral mucosa consists of two layers: the surface epithelium and the deeper lamina propria. The oral epithelium layer is very permeable to drugs. Thus, the sublingual delivery is a faster and more effective way of delivering high molecular weight drugs, such as B12.
Oral drug delivery is the method of swallowing a pharmaceutical drug with the intention of releasing it into the gastrointestinal (GI) tract. Once swallowed, a drug is released into the digestive tract's acidic, gastric environment before it is passed through to the liver, where it can be chemically altered and further broken down. Once the drug reaches the bloodstream, it will continue to circulate through the tissues and organs before being filtered by the liver and kidneys and excreted from the body.
Metabolism
Sublingual drug delivery avoids pre-systemic elimination in the GI tract, bypasses the liver first pass, and, depending on the drug, offers a better enzymatic flora for drug absorption.
Oral administration of drugs has disadvantages such as pre-systemic gastric enzymatic degradation within the GI tract, and further breakdown in hepatic (liver) first pass.
Dosing
Sublingual delivery is not metabolized in the digestive system, so a less active dose is needed to produce the desired bloodstream dose response.
Oral delivery causes significant loss of a drug due to the acidic stomach environment and liver metabolism. Thus, the bioavailability of oral delivery is 5-15% of the total oral application. A higher active dose is needed to be effective in achieving the necessary bloodstream dose-response.
Safety
Dosing of sublingual drugs is an important consideration because of high absorption and rapid permeability. While this can be life-saving in certain situations, like delivering a blood thinner to a patient in atrial fibrillation, a lower dose of the same blood thinner would be needed for long-term treatment. The advantages of targeted sublingual drug release include the reduction in dose frequency, drug side effects, and the fluctuation in circulating drug levels. Sublingual bioavailability is 80-100%, and by circumventing the liver path, it reduces toxicity and side effects caused by liver metabolites.
Drugs administered orally move through the digestive tract. They can interact with many tissues and organs where side effects can occur if a drug has unintended effects in the body. Drugs are also chemically altered in the body. The liver and kidneys can be prone to damage caused by drug metabolism in the organs. The harmful effects of drug toxicity often manifest over time and cannot be studied immediately.
Cost
Disintegrating tablet delivery creates a very high concentration in the sublingual region to be systemically absorbed across the mucosa. Sublingual delivery is more permeable and provides rapid absorption and good bioavailability in comparison to oral or buccal delivery systems, meaning the cost for the active dosing is less because less is needed. Because the delivery is sustained, less of the active material is needed, reducing the cost of production.
A higher amount of the active ingredient in a pharmaceutical drug is needed to increase the concentration of the medication to achieve desired dose-response, meaning higher cost associated with the amount of active(s) needed in a pharmaceutical drug, resulting in a lower cost to produce. Additionally, with sublingual delivery, there is no need to encase pharmaceuticals in hard shells to protect them from the GI tract, which increases the cost of oral delivery.

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